Intracoronary Cytoprotective Gene Therapy

Antithrombotic therapy with intracoronary stenting.

Following the first report of successful intracoronary stenting in humans, there was early enthusiasm for the potential of this technology to prevent occlusion or restenosis following angioplasty. Such enthusiasm however was quickly tempered by concerns regarding early thrombotic stent occlusion and its associated high risk of myocardial infarction or death, following the report of a 24% incide...

Mechanisms behind intracoronary radiation therapy failure.

1. Bourassa MG, Butnaru A, Lespérance J, Tardif JC. Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies. J Am Coll Cardiol 2003;41:351–9. 2. Kramer JR, Kitazume H, Proudfit WL, Sones FM Jr. Clinical significance of isolated coronary bridges: benign and frequent condition involving the left anterior descending artery. Am Heart J 1982;10...

ژن درمانی Gene Therapy

Cytoprotective-selective activated protein C therapy for ischaemic stroke.

Despite years of research and efforts to translate stroke research to clinical therapy, ischaemic stroke remains a major cause of death, disability, and diminished quality of life. Primary and secondary preventive measures combined with improved quality of care have made significant progress. However, no novel drug for ischaemic stroke therapy has been approved in the past decade. Numerous stud...

Intracoronary autologous CD34+ stem cell therapy for intractable angina.

BACKGROUND/OBJECTIVES A large number of patients with coronary artery disease experience angina that is not suitable for revascularization and is refractory to conventional medical therapy. Laboratory and preclinical studies have provided evidence for the safety and potential efficacy of autologous CD34+ stem cell therapies as treatment for angina. Clinical studies investigating intramyocardial...